Last update
9/13/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.6
USERS' SCORE
Good
Based on 9 Reviews
8
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Sodium (from Sodium Hyaluronate)
8 mg
<1%
Hyaluronic Acid (from Sodium Hyaluronate)
120 mg
†
Top Medical Research Studies
9
We examined a new treatment method for psoriasis using a dissolvable microneedle patch that delivers hyaluronic acid nanoparticles combined with methotrexate. This approach aims for better targeting of inflammatory skin cells while reducing side effects associated with traditional therapies. In our study with a mouse model, just one application of the patch led to a significant decrease in skin thickening and inflammation over a week. The results suggest that this innovative delivery method could improve treatment outcomes for some psoriasis patients.
Read More
9
Hyaluronic acid shows promise in RA
We synthesized a unique nanocomposite, HA-PBA-TiO, designed specifically for treating rheumatoid arthritis (RA). This innovative material shows impressive capabilities, such as boosting oxygen levels and reducing harmful reactive oxygen species in inflamed joints through photocatalytic reactions.
Our experiments demonstrated that when these nanoparticles target RA-affected areas, they help control excessive cell growth and improve the local environment. The results suggest that this approach offers a promising avenue for RA treatment, with effective outcomes backed by our testing.
Our experiments demonstrated that when these nanoparticles target RA-affected areas, they help control excessive cell growth and improve the local environment. The results suggest that this approach offers a promising avenue for RA treatment, with effective outcomes backed by our testing.
Read More
9
We explored a creative approach to treat rheumatoid arthritis, focusing on a new delivery method for tacrolimus using hyaluronic acid-coated nanogels.
By targeting inflamed joints specifically, this system reduced unwanted side effects and improved the effectiveness of tacrolimus therapy.
In trials with collagen-induced arthritis mice, the treatment showed impressive results, such as decreased joint swelling and inflammation.
Overall, this suggests that this hyaluronic acid-based delivery system could offer a safer and more effective treatment option for those suffering from rheumatoid arthritis.
By targeting inflamed joints specifically, this system reduced unwanted side effects and improved the effectiveness of tacrolimus therapy.
In trials with collagen-induced arthritis mice, the treatment showed impressive results, such as decreased joint swelling and inflammation.
Overall, this suggests that this hyaluronic acid-based delivery system could offer a safer and more effective treatment option for those suffering from rheumatoid arthritis.
Read More
Most Useful Reviews
9
Visible results
A good preparation with visible results after just one can; I plan to order more and highly recommend it to others.
Read More
7.5
Skin quality improved
I'm satisfied with the quality of this product. My skin condition has significantly improved, and I will order more.
Read More
7.5
Effective for skin
2 people found this helpful
Best for the money! I have previously used hyaluronic acid due to my autoimmune disorder, and this product is by far one of the best, especially for the price.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.6
- All Researches
9.5
We explored a novel injectable hydrogel designed to treat rheumatoid arthritis, which often causes joint lubrication issues and cartilage damage. This hydrogel incorporates modified hyaluronic acid and nanozymes that work together to reduce inflammation and promote cartilage repair.
By enhancing lubrication and offering sustained anti-inflammatory effects, this treatment aims to address both early and late-stage rheumatoid arthritis effectively. Ultimately, the hydrogel presents a comprehensive approach to managing this chronic autoimmune condition.
By enhancing lubrication and offering sustained anti-inflammatory effects, this treatment aims to address both early and late-stage rheumatoid arthritis effectively. Ultimately, the hydrogel presents a comprehensive approach to managing this chronic autoimmune condition.
Read More
9
We aimed to tackle the side effects of long-term use of tofacitinib, a well-known treatment for rheumatoid arthritis. By creating hyaluronic-acid-coated transethosomes, we delivered tofacitinib directly to affected areas, enhancing efficacy while reducing side effects. Our results showed significant anti-inflammatory effects, with marked reductions in inflammatory markers in treated rats compared to conventional delivery methods. This suggests that our targeted approach may offer a promising alternative for managing rheumatoid arthritis with fewer systemic impacts.
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9
Innovative dual-drug treatment examined
We explored the potential of hyalurosomes that combine dexamethasone and luteolin as a treatment for rheumatoid arthritis. In a study using a rat model, we observed significant reductions in inflammatory markers like TNF-α and MDA, suggesting these dual drug-loaded hyalurosomes could effectively decrease inflammation and swelling in joints.
Histological analysis showed results comparable to the negative control group, indicating strong therapeutic effects. While this research is promising, further studies with human subjects are essential to confirm these findings and evaluate long-term benefits.
Histological analysis showed results comparable to the negative control group, indicating strong therapeutic effects. While this research is promising, further studies with human subjects are essential to confirm these findings and evaluate long-term benefits.
Read More
9
We examined a new treatment method for psoriasis using a dissolvable microneedle patch that delivers hyaluronic acid nanoparticles combined with methotrexate. This approach aims for better targeting of inflammatory skin cells while reducing side effects associated with traditional therapies. In our study with a mouse model, just one application of the patch led to a significant decrease in skin thickening and inflammation over a week. The results suggest that this innovative delivery method could improve treatment outcomes for some psoriasis patients.
Read More
9
Hyaluronic acid shows promise in RA
We synthesized a unique nanocomposite, HA-PBA-TiO, designed specifically for treating rheumatoid arthritis (RA). This innovative material shows impressive capabilities, such as boosting oxygen levels and reducing harmful reactive oxygen species in inflamed joints through photocatalytic reactions.
Our experiments demonstrated that when these nanoparticles target RA-affected areas, they help control excessive cell growth and improve the local environment. The results suggest that this approach offers a promising avenue for RA treatment, with effective outcomes backed by our testing.
Our experiments demonstrated that when these nanoparticles target RA-affected areas, they help control excessive cell growth and improve the local environment. The results suggest that this approach offers a promising avenue for RA treatment, with effective outcomes backed by our testing.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Visible results
A good preparation with visible results after just one can; I plan to order more and highly recommend it to others.
Read More
7.5
Skin quality improved
I'm satisfied with the quality of this product. My skin condition has significantly improved, and I will order more.
Read More
7.5
Effective for skin
2 people found this helpful
Best for the money! I have previously used hyaluronic acid due to my autoimmune disorder, and this product is by far one of the best, especially for the price.
Read More
7.5
Facial skin improvement
2 people found this helpful
I've been taking it for two weeks now and have noticed a difference; my facial skin and lips look a bit plumped. I've just ordered two more bottles!
Read More
9
Skin elasticity improved
I decided to replenish my deficiencies with Jarrow Formulas Hyaluronic Acid capsules, as the thought of dubious injections stresses me. The capsules have noticeably improved my skin's dryness, elasticity, and hydration. Even as the cold weather has set in, I have no wounds or peeling skin, indicating a healthier overall appearance.
Read More
Frequently Asked Questions
7.5
Facial skin improvement
2 people found this helpful
I've been taking it for two weeks now and have noticed a difference; my facial skin and lips look a bit plumped. I've just ordered two more bottles!
9
Visible results
A good preparation with visible results after just one can; I plan to order more and highly recommend it to others.
7.5
Effective for skin
2 people found this helpful
Best for the money! I have previously used hyaluronic acid due to my autoimmune disorder, and this product is by far one of the best, especially for the price.
7.5
Skin quality improved
I'm satisfied with the quality of this product. My skin condition has significantly improved, and I will order more.
7.5
Strengthened joints
1 people found this helpful
An excellent product! I've struggled with climbing stairs, but this brand strengthens my joints, making it significantly easier. I'll definitely order more.
6
Not suitable treatment
It didn't suit me very well. I anticipated rejuvenation and reduction of wrinkles, which were achieved, but it increased my puffiness. I do have a tendency towards edema, so this could be an individual reaction. Overall, I won't be ordering again.
6
Less knee crunching
I decided to take one capsule a day for a month alongside collagen for a crunch in my knees. The crunching has lessened but hasn't completely disappeared.
9.5
We explored a novel injectable hydrogel designed to treat rheumatoid arthritis, which often causes joint lubrication issues and cartilage damage. This hydrogel incorporates modified hyaluronic acid and nanozymes that work together to reduce inflammation and promote cartilage repair.
By enhancing lubrication and offering sustained anti-inflammatory effects, this treatment aims to address both early and late-stage rheumatoid arthritis effectively. Ultimately, the hydrogel presents a comprehensive approach to managing this chronic autoimmune condition.
By enhancing lubrication and offering sustained anti-inflammatory effects, this treatment aims to address both early and late-stage rheumatoid arthritis effectively. Ultimately, the hydrogel presents a comprehensive approach to managing this chronic autoimmune condition.
8
Hyaluronic acid benefits uveitis treatment
We investigated how hyaluronic acid-curcumin nanoparticles (HA-CUR NPs) could help prevent autoimmune uveitis progression. Our research points to these nanoparticles having impressive antioxidant properties, helping counter inflammation and oxidative stress that drive uveitis. They appear to target specific receptors and activate protective cellular pathways, leading to reduced damage to the retina and enhanced blood flow in ocular areas. This suggests that HA-CUR NPs could be a promising new option for treating autoimmune-related eye conditions, although traditional treatments have had serious side effects.
9
Melatonin-hyalurosomes improve joint healing
We explored the potential of using melatonin encapsulated in hyalurosomes combined with a thermosensitive hydrogel for managing rheumatoid arthritis. This study involved testing the effectiveness of this treatment in a rat model of arthritis.
Our results showed that the melatonin-hyalurosomes in the hydrogel significantly improved joint healing and cartilage repair compared to standard hydrogel treatments. While as effective as traditional approaches, this method looks promising due to its minimal side effects.
Our results showed that the melatonin-hyalurosomes in the hydrogel significantly improved joint healing and cartilage repair compared to standard hydrogel treatments. While as effective as traditional approaches, this method looks promising due to its minimal side effects.
References
- He H, Zhang Q, Zhang Y, Qu S, Li B, et al. Injectable bioadhesive and lubricating hydrogel with polyphenol mediated single atom nanozyme for rheumatoid arthritis therapy. Nat Commun. 2025;16:2768. 10.1038/s41467-025-58059-z
- Tang W, Huang X, Yi YD, Cao F, Deng M, et al. Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway. J Nanobiotechnology. 2025;23:89. 10.1186/s12951-024-03082-3
- Chowdary P, Puppala ER, Putta CL, Maddila JR, Pulavarthy V, et al. Hyaluronic-Acid-Functionalized Tofacitinib Loaded Transethosomes for Targeted Drug Delivery in Rheumatoid Arthritis. ACS Appl Bio Mater. 2025;8:1594. 10.1021/acsabm.4c01743
- Zewail M, Gaafar PME, Abbas H, Elsheikh MA. Innovative rheumatoid arthritis management using injection replacement approach via dual therapeutic effects of hyalurosomes-encapsulated luteolin and dexamethasone. Colloids Surf B Biointerfaces. 2025;249:114497. 10.1016/j.colsurfb.2025.114497
- Zeng Y, Wu L, Jiang X, Hu Y, Jin Y, et al. Self-assembled hyaluronic acid nanoparticles delivered by polymeric microneedles for targeted and long-acting therapy of psoriasis. Int J Pharm. 2025;669:125073. 10.1016/j.ijpharm.2024.125073
- Liu X, Chen X, Fei Y, Zhang J, Yue O, et al. Locally Injectable, ROS-Scavenging, and ROS-/pH-Responsive Polymeric-Micelles-Embedded Hydrogels for Precise Minimally Invasive and Long-Lasting Rheumatoid Therapy. Adv Healthc Mater. 2025;14:e2403579. 10.1002/adhm.202403579
- Papp FR, Katko M, Csiki R, Galgoczi E, Molnar Z, et al. Characteristics of Hyaluronan Metabolism During Myofibroblast Differentiation in Orbital Fibroblasts. Invest Ophthalmol Vis Sci. 2024;65:13. 10.1167/iovs.65.13.13
- Chao M, Hua Z, Zhu J, Wu G, Fan L, et al. Hyaluronic acid modified prussian blue analogs/TiO₂ janus nanostructures through efficient charge separation to enhance photocatalytic-driven dual gas for achieve multimodal treatment of rheumatoid arthritis. Int J Biol Macromol. 2024;281:136567. 10.1016/j.ijbiomac.2024.136567
- Li Y, Wang X, Gao Y, Zhang Z, Liu T, et al. Hyaluronic acid-coated polypeptide nanogel enhances specific distribution and therapy of tacrolimus in rheumatoid arthritis. J Nanobiotechnology. 2024;22:547. 10.1186/s12951-024-02784-y
- Xu M, Fu T, Zhang C, An Z, Yan J, et al. Prolonged, staged, and self-regulated methotrexate release coupled with ROS scavenging in an injectable hydrogel for rheumatoid arthritis therapy. J Control Release. 2024;375:60. 10.1016/j.jconrel.2024.08.046
- Deng YS, Shen XY, Long MT, Zheng H, Li B, et al. [MMPs/pH synergically responsive XTS-Prussian blue nanoparticles inhibiting proliferation and migration of RAFLS assisted with laser irradiation]. Zhongguo Zhong Yao Za Zhi. 2024;49:2906. 10.19540/j.cnki.cjcmm.20240304.303
- Makled S, Abbas H, Ali ME, Zewail M. Melatonin hyalurosomes in collagen thermosensitive gel as a potential repurposing approach for rheumatoid arthritis management via the intra-articular route. Int J Pharm. 2024;661:124449. 10.1016/j.ijpharm.2024.124449
- Liu X, Zhang Q, Cao Y, Hussain Z, Xu M, et al. An Injectable Hydrogel Composing Anti-Inflammatory and Osteogenic Therapy toward Bone Erosions Microenvironment Remodeling in Rheumatoid Arthritis. Adv Healthc Mater. 2024;13:e2304668. 10.1002/adhm.202304668
- Zhu H, Huang D, Wang J, Zhao Y, Sun L. Viral Mimicking Polyplexes as Hierarchical Unpacking Vectors for Rheumatoid Arthritis Treatment. Adv Sci (Weinh). 2024;11:e2402888. 10.1002/advs.202402888
- Lee S, Choi S, Kim MS. Intra-articular hydrogel formulation prolongs the in vivo stability of Toll-like receptor antagonistic peptides for rheumatoid arthritis treatment. J Control Release. 2024;372:467. 10.1016/j.jconrel.2024.06.034
- Liu Y, Luo H, Liu B, Zhou T, Zhang Z, et al. Biomimetic NO Scavenging Hyaluronic Acid Nanoparticles Enable Targeted Delivery of MTX and Integrated Management of Rheumatoid Arthritis. Biomacromolecules. 2024;25:4557. 10.1021/acs.biomac.4c00556
